diff --git a/packages/tanstack-query/src/key.test.ts b/packages/tanstack-query/src/key.test.ts
index 85a8e5921..541b9876a 100644
--- a/packages/tanstack-query/src/key.test.ts
+++ b/packages/tanstack-query/src/key.test.ts
@@ -1,3 +1,6 @@
+import type { QueryKey } from '@tanstack/query-core'
+import { RPCJsonSerializer } from '@orpc/client'
+import { hashKey, partialMatchKey, skipToken } from '@tanstack/query-core'
 import { generateOperationKey } from './key'
 
 it('generateOperationKey', () => {
@@ -12,4 +15,37 @@ it('generateOperationKey', () => {
   expect(generateOperationKey(['path'], { prefix: '__prefix__' })).toEqual(['__prefix__', ['path'], {}])
   expect(generateOperationKey(['path'], { prefix: undefined })).toEqual([['path'], {}])
   expect(generateOperationKey(['path'], { prefix: '__prefix__', type: 'query', input: { a: 1 } })).toEqual(['__prefix__', ['path'], { type: 'query', input: { a: 1 } }])
+
+  expect(generateOperationKey(['planet', 'list'], { type: 'query', input: skipToken as any }))
+    .toEqual([['planet', 'list'], { type: 'query', skipToken: true }])
+})
+
+describe('generateOperationKey with skipToken', () => {
+  const serializer = new RPCJsonSerializer()
+
+  const hashers: [name: string, hash: (queryKey: QueryKey) => string][] = [
+    ['hashKey', hashKey],
+    ['RPCJsonSerializer', (queryKey) => {
+      const { json, meta } = serializer.serialize(queryKey)
+
+      return hashKey([
+        json,
+        meta?.map(entry => JSON.stringify(entry)).sort(),
+      ])
+    }],
+  ]
+
+  it.each(hashers)('does not collide with the no-input key when hashed with %s', (_, hash) => {
+    expect(hash(generateOperationKey(['planet', 'list'], { type: 'query', input: skipToken as any })))
+      .not
+      .toEqual(hash(generateOperationKey(['planet', 'list'], { type: 'query' })))
+  })
+
+  it('still partially matches keys without input', () => {
+    const skipped = generateOperationKey(['planet', 'list'], { type: 'query', input: skipToken as any })
+
+    expect(partialMatchKey(skipped, generateOperationKey(['planet', 'list']))).toBe(true)
+    expect(partialMatchKey(skipped, generateOperationKey(['planet', 'list'], { type: 'query' }))).toBe(true)
+    expect(partialMatchKey(skipped, generateOperationKey(['planet', 'list'], { input: {} }))).toBe(false)
+  })
 })
diff --git a/packages/tanstack-query/src/key.ts b/packages/tanstack-query/src/key.ts
index cb1a1e6c9..65cf60609 100644
--- a/packages/tanstack-query/src/key.ts
+++ b/packages/tanstack-query/src/key.ts
@@ -1,6 +1,7 @@
 import type { PartialDeep } from '@orpc/shared'
 import type { SerializableStreamedQueryOptions } from './stream-query'
 import type { OperationType } from './types'
+import { skipToken } from '@tanstack/query-core'
 
 export interface OperationKeyPrefixOptions {
   /**
@@ -16,9 +17,17 @@ export type OperationKeyOptions<TType extends OperationType, TInput> = Operation
   fnOptions?: TType extends 'streamed' ? SerializableStreamedQueryOptions : never
 }
 
+type OperationKeyContent<TType extends OperationType, TInput> = Omit<OperationKeyOptions<TType, TInput>, 'prefix'> & {
+  /**
+   * Set in place of `input` when the operation is disabled with `skipToken`,
+   * because query key hashers drop symbols.
+   */
+  skipToken?: TType extends 'mutation' ? never : true
+}
+
 export type OperationKey<TType extends OperationType, TInput>
-  = | [path: string[], options: Omit<OperationKeyOptions<TType, TInput>, 'prefix'>]
-    | [prefix: string, path: string[], options: Omit<OperationKeyOptions<TType, TInput>, 'prefix'>]
+  = | [path: string[], options: OperationKeyContent<TType, TInput>]
+    | [prefix: string, path: string[], options: OperationKeyContent<TType, TInput>]
 
 export function generateOperationKey<TType extends OperationType, TInput>(
   path: string[],
@@ -28,7 +37,9 @@ export function generateOperationKey<TType extends OperationType, TInput>(
     ...options.prefix !== undefined ? [options.prefix] : [],
     path,
     {
-      ...options.input !== undefined ? { input: options.input } : {},
+      ...options.input === skipToken
+        ? { skipToken: true }
+        : options.input !== undefined ? { input: options.input } : {},
       ...options.type !== undefined ? { type: options.type } : {},
       ...options.fnOptions !== undefined ? { fnOptions: options.fnOptions } : {},
     },
diff --git a/packages/tanstack-query/src/procedure-utils.test.ts b/packages/tanstack-query/src/procedure-utils.test.ts
index 3b7d9a381..d8fa0fa1a 100644
--- a/packages/tanstack-query/src/procedure-utils.test.ts
+++ b/packages/tanstack-query/src/procedure-utils.test.ts
@@ -1,4 +1,4 @@
-import { QueryClient, skipToken } from '@tanstack/query-core'
+import { InfiniteQueryObserver, QueryClient, QueryObserver, skipToken } from '@tanstack/query-core'
 import * as KeyModule from './key'
 import * as LiveQuery from './live-query'
 import { isProcedureUtilsOptions, mergeProcedureUtilsOptions, ProcedureUtils } from './procedure-utils'
@@ -441,6 +441,53 @@ describe('procedureUtils', () => {
   })
 })
 
+describe('skipToken queries do not share a query with unskipped ones', () => {
+  const client = vi.fn(async () => '__output__')
+  const utils = new ProcedureUtils<Record<never, never>, { search?: string } | undefined, string, Error>(['planet', 'list'], client)
+
+  it('.queryOptions', async () => {
+    const unskipped = new QueryObserver(queryClient, utils.queryOptions())
+    onTestFinished(unskipped.subscribe(() => {}))
+    await vi.waitFor(() => expect(unskipped.getCurrentResult().status).toBe('success'))
+
+    const skipped = new QueryObserver(queryClient, utils.queryOptions({ input: skipToken }))
+    onTestFinished(skipped.subscribe(() => {}))
+
+    expect(queryClient.getQueryCache().getAll()).toHaveLength(2)
+
+    await queryClient.invalidateQueries({ queryKey: utils.key() })
+
+    expect(unskipped.getCurrentResult().status).toBe('success')
+    expect(skipped.getCurrentResult().status).toBe('pending')
+    expect(client).toHaveBeenCalledTimes(2)
+  })
+
+  it('.infiniteOptions', async () => {
+    const unskipped = new InfiniteQueryObserver(queryClient, utils.infiniteOptions({
+      input: () => undefined,
+      initialPageParam: 0,
+      getNextPageParam: () => undefined,
+    }))
+    onTestFinished(unskipped.subscribe(() => {}))
+    await vi.waitFor(() => expect(unskipped.getCurrentResult().status).toBe('success'))
+
+    const skipped = new InfiniteQueryObserver(queryClient, utils.infiniteOptions({
+      input: skipToken,
+      initialPageParam: 0,
+      getNextPageParam: () => undefined,
+    }))
+    onTestFinished(skipped.subscribe(() => {}))
+
+    expect(queryClient.getQueryCache().getAll()).toHaveLength(2)
+
+    await queryClient.invalidateQueries({ queryKey: utils.key() })
+
+    expect(unskipped.getCurrentResult().status).toBe('success')
+    expect(skipped.getCurrentResult().status).toBe('pending')
+    expect(client).toHaveBeenCalledTimes(2)
+  })
+})
+
 describe('createProcedureUtils with options', () => {
   const client = vi.fn()
 
diff --git a/packages/tanstack-query/tests/e2e.test.tsx b/packages/tanstack-query/tests/e2e.test.tsx
index 082530034..f06806c08 100644
--- a/packages/tanstack-query/tests/e2e.test.tsx
+++ b/packages/tanstack-query/tests/e2e.test.tsx
@@ -55,6 +55,26 @@ it('case: with useQuery and skipToken', async () => {
   expect(result.current.status).toEqual('pending')
 })
 
+it('case: useQuery with and without skipToken do not share a query', async () => {
+  const { result } = renderHook(() => ({
+    unskipped: useQuery(orpc.stream.streamedOptions(), queryClient),
+    skipped: useQuery(orpc.stream.streamedOptions({ input: skipToken }), queryClient),
+  }))
+
+  await act(async () => {
+    await vi.waitFor(() => expect(result.current.unskipped.status).toEqual('success'))
+  })
+
+  expect(queryClient.getQueryCache().findAll({ queryKey: orpc.stream.key() })).toHaveLength(2)
+
+  await act(async () => {
+    await queryClient.invalidateQueries({ queryKey: orpc.stream.key() })
+  })
+
+  expect(result.current.unskipped.status).toEqual('success')
+  expect(result.current.skipped.status).toEqual('pending')
+})
+
 it('case: with streamed/useQuery', async () => {
   const { result } = renderHook(() => useQuery(orpc.stream.streamedOptions({
     queryFnOptions: {