diff --git a/src/main/resources/bidder-config/medianet.yaml b/src/main/resources/bidder-config/medianet.yaml
index de4b19a5142..1813150f14d 100644
--- a/src/main/resources/bidder-config/medianet.yaml
+++ b/src/main/resources/bidder-config/medianet.yaml
@@ -1,6 +1,14 @@
 adapters:
   medianet:
-    endpoint: https://prebid-adapter.media.net/rtb/pb/prebids2s?src={{PREBID_SERVER_ENDPOINT}}
+    # Media.net supports the following regional endpoint domains.
+    # Kindly set the endpoint below to match the datacenter region where this config is deployed:
+    #   US East  → https://prebid-adapter-useast.media.net/rtb/pb/prebids2s
+    #   US West  → https://prebid-adapter-uswest.media.net/rtb/pb/prebids2s
+    #   Asia     → https://prebid-adapter-asia.media.net/rtb/pb/prebids2s
+    #   Europe   → https://prebid-adapter-eu.media.net/rtb/pb/prebids2s
+    #
+    # Replace [REGION] in the endpoint URL with: useast | uswest | asia | eu
+    endpoint: https://prebid-adapter-[REGION].media.net/rtb/pb/prebids2s?src={{PREBID_SERVER_ENDPOINT}}
     ortb-version: "2.6"
     endpoint-compression: gzip
     meta-info: